A modular structure allows formulation experts to modify from incredibly more info hot-melt extrusion and continuous granulation jobs without having engineering the extruder technique.

GMP regular pharmaceutical variations from the ancillaries are offered with stainless-steel construction and dirt-restricted touch-display screen operator interface.

For dependable, controllable processing of hot-melt drug formulations which might be well suited for making use of PAT, the Thermo Scientific Pharma 24 Twin-screw Extruder guarantees minimized product changeover time and minimized scale-up risk, whilst making it possible for for quick and simple cleaning.

check out webinar - Employing hot melt extrusion as being a cost-effective approach to rising solubility of h2o insoluble APIs

The compounder with conical co- or counter-rotating screws is meant to lessen squander and decrease downtime essential for cleansing.

5 kg/h. The screw and barrel patterns are geometrically scalable across the whole Thermo Scientific portfolio of extruders from lab and pilot by way of to output scale.

utilizing a lab-scale extruder minimizes the use of expensive APIs and enables quickly and straightforward cleanse-up involving experiments.

the selection of the sufficient polymer being a matrix to kind secure reliable solutions is very important in HME. Polymers with a superior solubilization capability are specially acceptable given that they can dissolve large portions of medication. Polymers for hot-melt extrusion experiments are determined by distinct monomers and chemical structures, including homopolymers, copolymers, amphiphilic copolymers and also solubilizers and plasticizers.

getting the ideal API/excipients formulation and testing if this formulation is the proper applicant For decent-melt extrusion is usually tough. The Thermo Scientific Pharma mini HME Micro Compounder demands as tiny as 3 grams of total content to determine the ideal drug candidates for hot melt extrusion.

Used in quite a few industries, HME utilizes a mix of thermal and mechanical Strength to enhance ongoing processing for reproducible processing of materials, together with dust and solvent reduction and on line checking.

In the hot-melt extrusion approach, the API along with the excipients are fed into your extruder. All parts are sheared, heated, plastified, blended and dispersed, and finally formed by pressing them by way of a die opening. creating a HME-primarily based production project calls for control of many processing parameters that have an affect on last product or service good quality: Residence time distribution and precise mechanical Strength usage (SMEC) need to be thought of, as well as the temperature of your melt in the extruder die, the force in the die, and screw torque.

In pharmaceutical manufacturing, HME is utilized to disperse APIs in the matrix at the molecular stage, Consequently forming good methods. This enables drug delivery devices for badly soluble medication or specialized drug types for instance films for transdermal patches.

rapidly find the right Pharma pharma twin-screw extruder to fit your formulation development and production wants.

Polymers for hot-melt extrusion ought to exhibit thermoplastic qualities and has to be thermally secure at the proper extrusion temperature. In producing a HME drug procedure, the glass changeover and melting temperatures are significant aspects.

Thermo Scientific twin-screw extruders are built with equivalent geometries across their distinct sizes. This permits experimentation and feasibility projects formulated with a lab-scale (11 mm screw) instrument to be scaled-approximately professional measurement using a scientific tactic.

Consideration for each product need to consider into accountconsider the polymer's solubility inside a solvent, which might vary from higher lipophilicity to superior hydrophilicity.

Pharmaceutical suppliers are utilizing twin-screw extruders to mix molecules of Lively pharmaceutical substances (APIs) with proper polymers in scenarios the place drug components are badly soluble or unstable throughout processing.

The extrudability of a polymer is especially determined by Tg or Tm and melt viscosity. Most polymers display thixotropic conduct where the viscosity decreases for a functionality of escalating shear anxiety.

Present drug discovery methodology creates prospect medicine of escalating molecular dimension and lipophilicity, which leads to bad solubility and permeability. below ten% of latest drug candidates display both higher solubility and permeability, and thirty–forty% in the prescription drugs that appear on the planet Health Group vital Drug checklist have been claimed being improperly drinking water-soluble or lipophilic. HME disperses the drug within the matrix in a molecular stage by forming a sound solution.